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A poster on NeuroBo’s first candidate, NB-01, was presented at the NeuPSIG conference in London in May 2019. This study was conducted in Korea and shows that NB-01 was well tolerated in a Phase 2a safety study. The primary objective of this second Phase 2 study was to evaluate the efficacy of NB-01 in reducing pain in DPN. The secondary objective was to assess safety and tolerability of NB-01 in DPN.


Combined Application of UHPLC-QTOF/MS, HPLC-ELSD and 1 H-NMR Spectroscopy for Quality Assessment of DA-9801, A Standardised Dioscorea Extract. Kang KB, Ryu J, Cho Y, Choi SZ, Son M, Sung SH. Phytochem Anal. 2017 May;28(3):185-194. doi: 10.1002/pca.2659. Epub 2016 Dec 1.

Comparison of sensory tests and neuronal quantity of peripheral nerves between streptozotocin (STZ)-induced diabetic rats and paclitaxel (PAC)-treated rats. Jin HY, Lee NY, Ko HA, Lee KA, Park TS. Somatosens Mot Res. 2016 Sep - Dec;33(3-4):186-195. Epub 2016 Oct 18.

P2X1 Receptor-Mediated Ca2+ Influx Triggered by DA-9801 Potentiates Nerve Growth Factor-Induced Neurite Outgrowth. Back MJ, Lee HK, Lee JH, Fu Z, Son MW, Choi SZ, Go HS, Yoo S, Hwang SW, Kim DK. ACS Chem Neurosci. 2016 Nov 16;7(11):1488-1498. Epub 2016 Aug 22.

DA-9801 promotes neurite outgrowth via ERK1/2-CREB pathway in PC12 cells. Won JH, Ahn KH, Back MJ, Ha HC, Jang JM, Kim HH, Choi SZ, Son M, Kim DK. Biol Pharm Bull. 2015;38(2):169-78. doi: 10.1248/bpb.b14-00236. Epub 2014 Dec 5.

Dioscorea Extract (DA-9801) Modulates Markers of Peripheral Neuropathy in Type 2 Diabetic db/db Mice. Moon E, Lee SO, Kang TH, Kim HJ, Choi SZ, Son MW, Kim SY. Biomol Ther (Seoul). 2014 Sep;22(5):445-52. doi: 10.4062/biomolther.2014.051. Epub 2014 Sep 30.

Evaluation of the transporter-mediated herb-drug interaction potential of DA-9801, a standardized dioscorea extract for diabetic neuropathy, in human in vitro and rat in vivo. Song IS, Kong TY, Jeong HU, Kim EN, Kwon SS, Kang HE, Choi SZ, Son M, Lee HS. BMC Complement Altern Med. 2014 Jul 17;14:251. doi: 10.1186/1472-6882-14-251.

The protective effects of DA-9801 (Dioscorea extract) on the peripheral nerves in streptozotocin-induced diabetic rats. Lee KA, Jin HY, Baek HS, Park TS. J Nutr Sci Vitaminol (Tokyo). 2013;59(5):437-46.

Therapeutic Potential of Dioscorea Extract (DA-9801) in Comparison with Alpha Lipoic Acid on the Peripheral Nerves in Experimental Diabetes. Jin HY, Kim SH, Yu HM, Baek HS, Park TS. J Diabetes Res. 2013;2013:631218. doi: 10.1155/2013/631218. Epub 2013 Mar 12.

Evaluation of DA-9801, a new herbal drug for diabetic neuropathy, on metabolism-mediated interaction. Ji HY, Liu KH, Kong TY, Jeong HU, Choi SZ, Son M, Cho YY, Lee HS. Arch Pharm Res. 2013 Jan;36(1):1-5. doi: 10.1007/s12272-013-0014-9.

Novel botanical drug for the treatment of diabetic neuropathy. Choi SZ, Son MW. Arch Pharm Res. 2011 Jun;34(6):865-7. doi: 10.1007/s12272-011-0621-2.

Neurotrophic activity of DA-9801, a mixture extract of Dioscorea japonica Thunb. and Dioscorea nipponica Makino, in vitro. Kim N, Kim SH, Kim YJ, Kim JK, Nam MK, Rhim H, Yoon SK, Choi SZ, Son M, Kim SY, Kuh HJ. J Ethnopharmacol. 2011 Sep 1;137(1):312-9. doi: 10.1016/j.jep.2011.05.032. Epub 2011 May 31.